Overcoming Chemoresistance in Advanced Ovarian Cancer Via Targeting Hypoxia
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The goal of this non-randomized prospective study is to use 18F-EF5-PET/CT imaging to identify and locate intraabdominal hypoxic ovarian cancer lesions. With targeted surgical sampling, precisely obtain hypoxic and potentially chemoresistant cancer tissue for our analyses and identify key molecular differences between hypoxic and non-hypoxic tumors within the same patient. A portion of advanced stage EOC are inoperable at diagnosis and can be treated with neoadjuvant chemotherapy (NACT) before surgery. This approach offers a unique opportunity to study how hypoxic tumor areas respond to treatment.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 79
Healthy Volunteers: f
View:
• newly diagnosed advanced epithelial ovarian, primary peritoneal or fallopian tube cancer.
• age 18-79 years
• informed concent
Locations
Other Locations
Finland
Turku University hospital
RECRUITING
Turku
Contact Information
Primary
Maren Laasik, MD
maren.laasik@utu.fi
+35823130000
Time Frame
Start Date: 2017-03-09
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 40
Treatments
Experimental: PDS
18F-EF5 PET/CT and 18F-FDG PET/CT scan prior to primary cytoreductive surgery and targeted sample collection during primary cytoreductive surgery
Experimental: IDS
18F-EF5 PET/CT and 18F-FDG PET/CT scans prior to diagnostic laparoscopy and after neoadjuvant chemotherapy before interval cytoreductive surgery .~Targeted sample collection during diagnostic laparoscopy and interval cytoreductive surgery
Related Therapeutic Areas
Sponsors
Leads: Turku University Hospital